Computational Analysis for Regulation of Podophyllotoxin Biosynthesis Pathway in Podophyllum with Potential Substitute Species

Podophyllum species, the source of important secondary metabolite, podophyllotoxin, is over-exploited for production anti-cancer drugs endangering this genus globally. Lack complete knowledge on podophyllotoxin biosynthesis a major drawback in its cultivation and identification alternative plants. The current study secoisolariciresinol dehydrogenase, dirigent protein oxidase pluviatolide synthase identifies their role regulating biosynthesis. present computational analysis proposes correlating interconnected network pathways besides identifying potential substitute species accounting possible reason variation yield from different